Differential Protein Expression in Exponential and Stationary Growth Phases of Mycobacterium avium subsp. hominissuis 104

Mycobacterium avium complex (MAC) is the most common non-tuberculous mycobacterium (NTM) and causes different types of pulmonary diseases. While genomic transcriptomic analysis 104 (M. 104) has been extensive, little known about proteomics M. 104. We utilized technology to analyze changes in whole proteome during exponential stationary growth phases. found 12 dys-regulated proteins; up-regulated protein hits phase were involved aminopeptidase, choline dehydrogenase, oxidoreductase, ATP binding, while down-regulated proteins acetyl-CoA acetyltransferase, universal stress protein, catalase peroxidase, elongation factor (Tu). The differently expressed between phases implicated metabolism response, pointing functional adaptation cells environment. Proteomic could participate understanding course infection, mechanisms virulence, means survival, possible targets for treatment.